Lamontagne, François;
Agoritsas, Thomas;
Siemieniuk, Reed;
Rochwerg, Bram;
Bartoszko, Jessica;
Askie, Lisa;
Macdonald, Helen;
Amin, Wagdy;
Bausch, Frederique Jacquerioz;
Burhan, Erlina;
Cecconi, Maurizio;
chanda, Duncan;
Quoc Dat, Vu;
Du, Bin;
Geduld, Heike;
Gee, Patrick;
Nerina, Harley;
Hashimi, Madiha;
Hunt, Beverley;
Kabra, Sushil;
Kanda, Seema;
Kawano-Dourado, Leticia;
Kim, Yae-Jean;
Kissoon, Niranjan;
Kwizera, Arthur;
Leo, Yee-Sin;
Mahaka, Imelda;
Manai, Hela;
Mino, Greta;
Nsutebu, Emmanuel;
Pshenichnaya, Natalia;
Qadir, Nida;
Ranganathan, Shalini Sri;
Sabzwari, Saniya;
Sarin, Rohit;
Sharland, Michael;
Shen, Yinzhong;
Souza, Joao;
Stegemman, Miriam;
Ugarte, Sebastian;
Venkatapuram, Sridhar;
Vuyiseka, Dubula;
Preller, Jacobus;
Brignardello-Petersen, Romina;
Kum, Elena;
Qasim, Lyubov;
Zeraatkar, Dena;
Owen, Andrew;
Guyatt, Gordon;
Lytvyn, Lyubov;
Diaz, Janet;
Vandvik, Per;
Jacobs, Michael.
Clinical question What is the role of drugs in preventing covid-19? Why does this matter?There is widespread interest in whether drug interventions can be used for the prevention of covid-19, but there is uncertainty about which drugs, if any, are effective. The first version of this living guideline foc...
Rochwerg, Bram;
Agoritsas, Thomas;
Lamontagne, François;
Leo, Yee-Sin;
Macdonald, Helen;
Agarwal, Arnav;
Zeng, Linan;
Lytvyn, Lyubov;
Appiah, John Adabie;
Amin, Wagdy;
Arabi, Yaseen;
Blumberg, Lucille;
Burhan, Erlina;
Bausch, Frederique;
Calfee, Carolyn S;
Cao, Bin;
Cecconi, Maurizio;
Chanda, Duncan;
Cooke, Graham;
Du, Bin;
Dunning, Jake;
Geduld, Heike;
Gee, Patrick;
Hashimi, Madiha;
Hui, David S;
Kabra, Sushil;
Kanda, Seema;
Kawano-Dourado, Leticia;
Kim, Yae-Jean;
Kissoon, Niranjan;
Kwizera, Arthur;
Laake, Jon Henrik;
Machado, Flavia R;
Mahaka, Imelda;
Manai, Hela;
Mino, Greta;
Nsutebu, Emmanuel;
Pshenichnaya, Natalia;
Qadir, Nida;
Sabzwari, Saniya;
Sarin, Rohit;
Sharland, Michael;
Shen, Yinzhong;
Ranganathan, Shalini Sri;
Souza, Joao;
Ugarte, Sebastian;
Venkatapuram, Sridhar;
Dat, Vu Quoc;
Vuyiseka, Dubula;
Wijewickrama, Ananda;
Maguire, Brittany;
Zeraatkar, Dena;
Bartoszko, Jessica;
Ge, Long;
Brignardello-Petersen, Romina;
Siemieniuk, Reed;
Guyatt, Gordon;
Diaz, Janet;
Jacobs, Michael;
Vandvik, Per Olav.
What is the role of drug interventions in the treatment of patients with covid-19? The latest version of this WHO living guidance focuses on remdesivir, following the 15 October 2020 preprint publication of results from the WHO SOLIDARITY trial. It contains a weak or conditional recommendation against th...
Rochwerg, Bram;
Agarwal, Arnav;
Zeng, Linan;
Leo, Yee-Sin;
Appiah, John Adabie;
Agoritsas, Thomas;
Bartoszko, Jessica;
Brignardello-Petersen, Romina;
Ergan, Begum;
Ge, Long;
Geduld, Heike;
Gershengorn, Hayley B;
Manai, Hela;
Huang, Minhua;
Lamontagne, François;
Kanda, Seema;
Kawano-Dourado, Leticia;
Kurian, Linda;
Kwizera, Arthur;
Murthy, Srinivas;
Qadir, Nida;
Siemieniuk, Reed;
Silvestre, Maria Asuncion;
Vandvik, Per Olav;
Ye, Zhikang;
Zeraatkar, Dena;
Guyatt, Gordon.
Clinical question: What is the role of remdesivir in the treatment of severe covid-19? This guideline was triggered by the ACTT-1 trial published in the New England Journal of Medicine on 22 May 2020.Remdesivir has received worldwide attention as a potentially effective treatment for severe covid-19. Aft...
Honarmand, Kimia;
Um, Kevin John;
Belley-Côté, Emilie P;
Alhazzani, Waleed;
Farley, Chris;
Shannon M, Fernando;
Fiest, Kirsten;
Grey, Donna;
Hajdini RN, Edita;
Herridge, Margaret;
Hrymak, Carmen;
Møller, Morten Hylander;
Kanji, Salmaan;
Lamontagne, François;
Lauzier, François;
Mehta, Sangeeta;
Paunovic, Bojan;
Singal, Rohit;
Tsang, Jennifer Ly;
Wynne, Christine;
Rochwerg, Bram.
Purpose: Hemodynamic management of adults with distributive shock often includes the use of catecholamine-based vasoconstricting medications. It is unclear whether adding vasopressin or vasopressin analogues to catecholamine therapy is beneficial in the management of patients with distributive shock. The...
Tis part II of the guidelines for the diagnosis and management of critical illness-related corticosteroid insufciency (CIRCI) in critically ill patients is related to acute illnesses that may be complicated by CIRCI. We followed
strictly the same methodology as for part I (see Appendix 1 in Supplementary...
Raghu, Ganesh;
Rochwerg, Bram;
Zhang, Yuan;
Cuello Garcia, Carlos A;
Azuma, Arata;
Behr, Juergen;
Brozek, Jan L;
Collard, Harold R;
Cunningham, William;
Homma, Sakae;
Johkoh, Takeshi;
Martinez, Fernando J;
Myers, Jeffrey;
Protzko, Shandra L;
Richeldi, Luca;
Rind, David;
Selman, Moisés;
Theodore, Arthur;
Wells, Athol U;
Hoogsteden, Henk;
Schünemann, Holger J.
Background: This document updates the American Thoracic Society/European Respiratory Society/Japanese Respiratory Society/Latin American Thoracic Association guideline on idiopathic pulmonary fibrosis treatment. Methods: Systematic reviews and, when appropriate, meta-analyses were performed to summarize ...
